Dual effects of phytoestrogens result in u-shaped dose-response curves.
نویسندگان
چکیده
منابع مشابه
Dual effects of phytoestrogens result in u-shaped dose-response curves.
Endocrine disruptors can affect the endocrine system without directly interacting with receptors, for example, by interfering with the synthesis or metabolism of steroid hormones. The aromatase that converts testosterone to 17beta-estradiol is a possible target. In this paper we describe an assay that simultaneously detects aromatase inhibition and estrogenicity. The principle is similar to tha...
متن کاملU-shaped dose response in vasomotor tone: a mixed result of heterogenic response of multiple cells to xenobiotics.
U-shaped response has been frequently encountered in various biological areas including epidemiology, toxicology, and oncology. Despite its frequent observation, the theory of U-shaped response has been crippled by the lack of a robust mechanism underlying and incomplete in vitro and in vivo correlation. In the present study, a novel mechanism is provided for a U-shaped response, based on the f...
متن کاملSuperoxide Dismutase and Bell-shaped Dose Response Curves
BOOK April 29 – 30, 2008 University of Massachusetts, Amherst, MA Edward J. Calabrese, Ph.D. Paul T. Kostecki, Ph.D. Conference Directors
متن کاملSuperoxide dismutase, lipid peroxidation, and bell-shaped dose response curves.
Cellular metabolism generates the cytotoxic superoxide free radical, O(2).(-), and a family of enzymes called superoxide dismutases (SOD) protects us from O(2).(-) by catalyzing its conversion to O(2) and H(2)O(2). Superoxide production increases in a wide variety of pathological states, especially those involving inflammation or ischemic injury. Most of the literature has described systems whe...
متن کاملModeling U Shaped Performance Curves in Ongoing Development
This paper details a simple and general account, and model, of the U-shaped curve phenomena apparent in many developmental psychology experiments. The model replicates both the general form of the U-shape performance in ongoing development and accounts for additional observations in the psychology literature such as the effect of noise in Switch task experiments. This leads to predictions both ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2002
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.02110743